| EPSRC Reference: |
GR/N36066/01 |
| Title: |
MECHANISM AND APPLICATION OF CHIRAL LEWIS-ACID CATALYSED AZA-DIELS-ALDER REACTIONS |
| Principal Investigator: |
Whiting, Professor A |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
UMIST |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 2000 |
Ends: |
31 August 2001 |
Value (£): |
109,024
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| EPSRC Research Topic Classifications: |
| Asymmetric Chemistry |
Catalysis & Applied Catalysis |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
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| Panel History: |
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Summary on Grant Application Form |
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The programme involves the use of a range of physical organic and analytical methods to determine the mechanism of action of four catalytic asymmetric systems which were recently discovered in our laboratories. These catalysts induce high asymmetric systems which were recently discovered in our laboratories. These catalysts induce high asymmetric induction in the aza-Diels-Alder reaction of an N-aryl electron deficient imine with Danishefsky's diene. The mechanistic study will also involve an in-depth study of the scope of the catalytic processes, examining its applicability on different diene and dienophile combinations. The final part of the project will involve a detailed study to develop new synthetic methods for the conversion of the aza-Diels-Alder adducts into useful asymmetric synthons, particularly for the preparation of new potential alpha- and beta-glucosidase inhibitors.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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