Details of Grant 

EPSRC Reference:	GR/N32846/01
Title:	THE CATALYTIC GENERATION & TRAPPING OF CHIRAL ENOLATES
Principal Investigator:	Willis, Professor M
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department:	Chemistry
Organisation:	University of Bath
Scheme:	Standard Research (Pre-FEC)
Starts:	01 November 2000	Ends:	31 October 2003	Value (£):	68,631
EPSRC Research Topic Classifications:	Chemical Synthetic Methodology
EPSRC Industrial Sector Classifications:	Chemicals
Related Grants:
Panel History:
Summary on Grant Application Form
The proposed research deals with the development of methodology for the catalytic generation of chiral enolates and their subsequent use in enantioselective aldol reactions. Soft enolisation conditions combining a chiral Lewis acid together with an amine base will be used to create a chiral base . The chiral catalyst is involved in both enolate generation and addition steps of the process. Earlier generation of an enolate (or equivalent) is not needed.Isothiocyanate substituted N-acyl oxazolidinones will be employed as the initial reaction substrates. Importantly these substrates allow in-situ modification of the aplha-substituent post carbon-carbon bond formation. This is crucial as it decreases the acidity of the aplha proton present in the product and thus limits production racemisation.
Key Findings
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Potential use in non-academic contexts
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Impacts
Description This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk Summary Date Materialised
Sectors submitted by the Researcher
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Project URL:
Further Information:
Organisation Website:	http://www.bath.ac.uk