| EPSRC Reference: |
GR/N32532/01 |
| Title: |
DYNAMIC RESOLUTION OF ORGANOMETALLIC SPECIES AND APPLICATION IN SYNTHESIS |
| Principal Investigator: |
Coldham, Professor I |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
University of Exeter |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 2000 |
Ends: |
30 September 2003 |
Value (£): |
73,116
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| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
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| Panel History: |
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Summary on Grant Application Form |
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The research described in this proposal aims to investigate some of the factors affecting the stability and reactivity of chiral organometallic species. The use of dynamic resolution of chiral organolithium and other organometallic species will be studied in order to gain information concerning the factors affecting the configurational stability of organometallic species. Addition of a variety of electrophiles will permit the study of the mode of reaction (retention or inversion) and give access to many different enantiomerically enriched products. The chemistry will be applied to the preparation of substituted heteroaromatics, piperidines and other heterocycles of biological significance.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.ex.ac.uk |