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Details of Grant 

EPSRC Reference: GR/N28696/01
Title: TOWARDS NEW RHENIUM AND COPPER BASED RADIOPHARMACEUTICALS
Principal Investigator: Dilworth, Professor J
Other Investigators:
George, Professor A J T Blower, Professor P
Researcher Co-Investigators:
Project Partners:
Department: Oxford Chemistry
Organisation: University of Oxford
Scheme: Standard Research (Pre-FEC)
Starts: 01 February 2001 Ends: 30 April 2004 Value (£): 171,859
EPSRC Research Topic Classifications:
Biological & Medicinal Chem. Drug Formulation & Delivery
EPSRC Industrial Sector Classifications:
Chemicals Healthcare
Pharmaceuticals and Biotechnology
Related Grants:
Panel History:  
Summary on Grant Application Form
The mechanism of the reduction of [Re04]- with substitute hydrazines will be investigated and developed as a route to new Re complexes in intermediate oxidation states with oxo.diazene and isodiazene cores. A wide range of polydentate ligands will be added to these cores to produce stable complexes which can either be conjugated to biological targeting molecules or have redox/stability characteristics that enable them to target selectively hypoxic cells. In parallel single chain antibody fragments, specific for cancer cell antigens, will be prepared and conjugated using standard methods to new and established Re and Cu complexes. Some new coordination chemistry of copper, together with the extension of some existing chemistry will also be explored with the aim of generating complexes capable of selective reductive trapping in hypoxic cells and tissue. If necessary addition selectivity will be introduced by conjugation to FsVs or hypoxic selective groups such as nitroimidazoles. Complexes with nitrogen mustard related ligands offer the possibility of simultaneous targeted delivery of a cytotoxin and radiation to a tumour site. Radiolabelling protocols will be established for lead Cu and Re complexes and their conjugates and binding, cell uptake (hypoxic selectivity) and biodistribution studies carried out.
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Organisation Website: http://www.ox.ac.uk