| EPSRC Reference: |
GR/N28481/01 |
| Title: |
ACCELERATED TEST METHODS FOR EVALUATION OF BIOABSORBAB LE POLYMERS USED IN SURGICAL APPLICATIONS |
| Principal Investigator: |
Buchanan, Professor FJ |
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| Department: |
Sch Mechanical and Aerospace Engineering |
| Organisation: |
Queen's University of Belfast |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 2000 |
Ends: |
30 September 2003 |
Value (£): |
58,669
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Summary on Grant Application Form |
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The long term goal of biomaterials research lies in tissue regeneration, not replacement. Bioactive scaffolds can be used either to engineer in-vitro living cellular constructs for transplantation, or as absorbable bioactive networks to activate in-vivo mechanisms for tissue regeneration. The ideal scaffold should provide high strength initially, then gradually degrade, transferring mechanical loads to regenerating tissue (eg in repair of ligaments and tendons).A draft ISO standard exists for in-vitro ageing of these materials. However no accelerated test methods exist which will predict to behaviour of bioabsorbable polymers in-vivo.The aim of this work will be to develop accelerated test methods and use these to establish an overview of the pattern of degradation. An important aspect of the work will be to link changes in mechanical properties to microstructural changes in these polymers which occur during degradation. The test methods will be used to assess how factors such as material, processing route, sterilisation, packaging and application influence the rate and pattern of polymer degradation.EngProg\
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.qub.ac.uk |