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Details of Grant 

EPSRC Reference: GR/N23035/01
Title: NEW APPROACHES TO BIOLOGICALLY ACTIVE AMINES USING COBALT TEMPLATE SYNTHESES
Principal Investigator: Golding, Professor B
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department: School of Chemistry
Organisation: Newcastle University
Scheme: Standard Research (Pre-FEC)
Starts: 28 October 2000 Ends: 27 October 2003 Value (£): 170,914
EPSRC Research Topic Classifications:
Chemical Synthetic Methodology
EPSRC Industrial Sector Classifications:
Pharmaceuticals and Biotechnology No relevance to Underpinning Sectors
Related Grants:
Panel History:  
Summary on Grant Application Form
The project is concerned with the development of new synthetic methodology based on stable, non-dissociable cobalt (III) templates. This methodology will be applied to the synthesis of unusual polyamines, amino acids and heterocycles, some of which may exhibit significant activity against biological targets implicated in the molecular pathology of cancer and other diseases. There are many advantages to the proposed synthetic strategy with cobalt templates over the use of traditional organic protecting and activating groups, including the ability to obtain single enantiomers of chiral molecules by exploiting the chirality of the cobalt centre. The research will be largely focused on imine complexes as these present many opportunities to achieve C-C and C-N bond formations, which can be coupled, if required, within the same reaction sequence. The acidic/basic and electrophillic/nucleophillic character of different sites can be manipulated to orchestrate the chemistry, which can lead via a cyclisation to heterocyclic products.
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Organisation Website: http://www.ncl.ac.uk