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Details of Grant 

EPSRC Reference: GR/N20034/01
Title: NOVEL OPTICAL MANIPULATION TECHNIQUES AND THEIR APPLICATION TO CHROMATID BREAK STUDIES
Principal Investigator: Dholakia, Professor K
Other Investigators:
Bryant, Dr P Sibbett, Professor W
Researcher Co-Investigators:
Project Partners:
University of Glasgow
Department: Physics and Astronomy
Organisation: University of St Andrews
Scheme: Standard Research (Pre-FEC)
Starts: 01 September 2000 Ends: 28 February 2003 Value (£): 172,059
EPSRC Research Topic Classifications:
Cells Genomics
EPSRC Industrial Sector Classifications:
No relevance to Underpinning Sectors
Related Grants:
Panel History:  
Summary on Grant Application Form
The programme described will have two major areas that overlap strongly between the Schools of Physics and Biology at the University of St Andrews.a. The development and characterisation of an optical tweezer arrangement using Laguerre-Gaussian light beams. The first full 3D evaluation of these light beams should lead to a tweezing system that requires reduced input power and thus limits any optical damage that may occur to the trapped sample. Additionally characterisation of particle manipulation will be performed using interfering light beams for enhanced translational and rotational control of trapped objects in the tweezer. These studies will be directly linked to the fixed metaphase chromatid studies in part (b).b. The optical microdissection and subsequent manipulation of chromosome fragments. Using a 532nm laser, small chromatid fragments will be generated with precision. Optical tweezers will then be used (utilising work from part (a)) to move the fragments to a suitable well for access by a micropipette for amplification using Polymerased Chain Reaction.EngProg\
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Organisation Website: http://www.st-and.ac.uk