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Details of Grant 

EPSRC Reference: GR/N18673/01
Title: 3D MR MYOCARDIAL PERFUSION IMAGING WITH ADAPTIVE SLICE TRACKING & TRACER KINETIC MODELLING
Principal Investigator: Yang, Professor G
Other Investigators:
Firmin, Professor D Pennell, Professor DJ
Researcher Co-Investigators:
Project Partners:
Department: Dept of Computing
Organisation: Imperial College London
Scheme: Standard Research (Pre-FEC)
Starts: 01 November 2000 Ends: 31 January 2004 Value (£): 211,442
EPSRC Research Topic Classifications:
Image & Vision Computing
EPSRC Industrial Sector Classifications:
Healthcare
Related Grants:
Panel History:  
Summary on Grant Application Form
The recent development of MR myocardial perfusion imaging has extended the role of cardiovascular MR in the evaluation of ischaemic heart disease beyond the situations where there have already been gross myocardial changes such as acute infarction or scarring. The ability to non-invasively evaluate cardiac perfusion abnormalities before pathologic effects occur, or as follow-up to therapy, is important to the management of patients with coronary artery disease. The goal of this proposal is to develop a spatio-temporally registered three-dimensional magnetic resonance myocardial perfusion imaging technique. In 3D myocardial perfusion imaging, a complete volumetric data set has to be acquired for each cardiac cycle, cardiac and respiratory motion during image acquisition has to be corrected. In this proposal, the registration of the myocardium during the contract uptake is decoupled and to be accomplished in two different steps. The through plane motion of the heart during multi-slice coverage of the entire myocardium is to be adaptively tracked in real-time during imaging. The translational motion and deformation of the myocardium within each image plane, on the other hand, will be registered by using a free-form deformation model coupled with tracer kinetic modelling.
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Organisation Website: http://www.imperial.ac.uk