| EPSRC Reference: |
GR/N18444/01 |
| Title: |
ASYMMETRIC CATALYSIS: DEVELOPMENT OF METHODS FOR THE SYNTHESIS OF COMPLEX AMINO ACIDS AND RELATED COMPOUNDS |
| Principal Investigator: |
Lygo, Professor B |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Sch of Chemistry |
| Organisation: |
University of Nottingham |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 2001 |
Ends: |
30 September 2004 |
Value (£): |
73,668
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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We have recently shown that the asymmetric phase-transfer catalysed alkylation of glycine imines can be an effective method for the synthesis of amino acid derivatives. Here we propose to expand the range of electrophiles thAt can be used, enabling access to a wide range of structurally diverse alpha-amino acids. We also aim to investigate application of this chemistry in the synthesis of a number of key biologically-active molecules of varying complexity. This will enable us to address strategic issues associated with the construction of such target structures as well as providing efficient access to these important materials.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.nottingham.ac.uk |