| EPSRC Reference: |
GR/N16044/01 |
| Title: |
ENANTIOMERIC DISCRIMINATION OF ORGANO-FLUORINE COMPOUNDS USING THE ORSAY 2H-NMR METHOD |
| Principal Investigator: |
O'Hagan, Professor D |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
University of St Andrews |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
14 May 2001 |
Ends: |
13 August 2004 |
Value (£): |
141,268
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| EPSRC Research Topic Classifications: |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Electronics |
| Pharmaceuticals and Biotechnology |
No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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This programme has two key objectives:Firstly the stereochemical course of the fluorination enzyme operating in Streptomcyces cattleya will be evaluated. This will require preparing ( R ) and (S) [1-2H2]-glycerols for feeding experiments. The e.e of the resultant chiral [2H]-fluoroacetate will then be determined using the Orsay 2H-NMR method. A sample of [2H]-fluoroacetate of known configuration will be required as a reference compound. A knowledge of the stereochemical course of this enzyme will contribute to our understanding of the mechanism of this unique bio-transformation.Secondly a series of compounds will be pepared with fluorine at remote stereogenic centres. The limits of the enantiomeric discrimination of these systems will be explored by preparing fluoroalkanes isotopically enriched with deuterium also at the stereogenic centre. This study will be developed towards the preparation of homochiral organofluorine fatty acids to assess the influence of chirality on the properties of the materials.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.st-and.ac.uk |