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Details of Grant 

EPSRC Reference: GR/N13722/01
Title: FLUORESCENCE PHOTOPHYSICS SENSING OF GLUCOSE IN DIABETES
Principal Investigator: Pickup, Professor J
Other Investigators:
Gnudi, Professor L Birch, Professor D
Researcher Co-Investigators:
Project Partners:
Department: Chemical Pathology
Organisation: Kings College London
Scheme: Standard Research (Pre-FEC)
Starts: 01 January 2001 Ends: 31 December 2003 Value (£): 72,388
EPSRC Research Topic Classifications:
Lasers & Optics
EPSRC Industrial Sector Classifications:
Healthcare
Related Grants:
GR/N14224/01
Panel History:  
Summary on Grant Application Form
1. Non-invasive glucose sensing is a priority to improve the everyday management of diabetic patients, especially for detection of hypoglycaemia. The most studied approach, near-infrared spectroscopy, does not yet have sufficient accuracy and precision for clinical application. We are therefore investigating a series of new strategies for non-invasive glucose monitoring primarily based on measurement of fluorescence lifetimes, rather than intensity. These include the measurement of metabolism related changes in intrinsic fluorescence of tissue and detection of glucose changes by vital fluorescent dyes which signal cellular metabolic activity. Time-domain fluorescence measurements have several advantages for tissue sensing, including freedom from interference from light scatter and changes in fluorophore concentration. To further facilitate this technology, we propose to develop and validate several in vitro cell models, including cell culture systems established at different glucose concentrations, adipose tissue biopsies and blood samples from patients and controls and liposome dispersions, which will enable the photophysics of metabolism-related fluorescence to be studied. Detailed kinetics of single and multi-photon excited fluorescence decay lifetimes and anisotropy will be related to metabolic changes. This proposal will further extend our recently-established clinical diabetes photophysics collaborative initiative, and train both a Life Sciences and Physical Sciences graduate in relevant research techniques.
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