| EPSRC Reference: |
GR/N08520/01 |
| Title: |
TOTAL SYNTHESIS OF THE MICROTUBULE-STABILISING AGENT LAULIMALIDE |
| Principal Investigator: |
Paterson, Professor I |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
University of Cambridge |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 May 2000 |
Ends: |
31 October 2003 |
Value (£): |
169,888
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
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| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
No relevance to Underpinning Sectors |
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| Panel History: |
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Summary on Grant Application Form |
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Laulimalide, also known as fijianolide B, is a 20-membered macrolide first isolated from the Indonesian sponge Hyattella sp. Laulimalide represents a new class of bioactive macrolide that displays remarkable potency as an antimitotic agent and has potential for the treatment of various human cancers. Recent studies have shown that laulimalide shares the same microtubule stabilising mechanism as the clinically important anticancer drug Taxol and, most significantly, retains antimitotic potency against Taxol-resistant cancer cells. This programme plans to develop a stereocontrolled synthesis of laulimalide and explore novel aspects of macrocyclic stereocontrol for the synthesis of such bioactive macrolides. In addition, the rational design of potential microtubule-stablising drugs will be initiated based on pharmacophore models for laulimalide and other Taxol-like molecules.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.cam.ac.uk |