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Details of Grant 

EPSRC Reference: GR/N07233/01
Title: INTEGRATED PROCESS DESIGN FOR CATALYTIC REACTIONS IN FLUOROUS BIPHASIC SYSTEMS
Principal Investigator: Cole-Hamilton, Professor D
Other Investigators:
Researcher Co-Investigators:
Project Partners:
ICI Kvaerner Process
Department: Chemistry
Organisation: University of St Andrews
Scheme: Standard Research (Pre-FEC)
Starts: 01 September 2000 Ends: 31 May 2004 Value (£): 90,985
EPSRC Research Topic Classifications:
Catalysis & Applied Catalysis
EPSRC Industrial Sector Classifications:
Manufacturing Construction
Pharmaceuticals and Biotechnology Chemicals
Related Grants:
GR/N07172/01 GR/N07202/01
Panel History:  
Summary on Grant Application Form
Homogeneous catalysts can provide very high activity and selectivity towards industrially desirable products, but their commercialisation can be hampered by the problem of their separation from products and solvents and hence the difficulties associated with their recycling. We shall investigate the use of fluorous biphase systems, where under some conditions a fluorous solvent is immiscible with an organic solvent containing the substrate and the organic products. Separation can then be achieved by decanting one phase from the other. This is a generic technology, that is applicable to a wide variety of homgeneous catalytic systems, although we shall concentrate on three major systems: hydroformylation of long chain alkenes which is important for the production of soap and detergent alcohols, asymmetric hydroformylation as a route to pharmaceuticals intermediates and synthesis of methacrylate esters of long chain alcohols for use in speciality polymers. We propose a collaborative programme bringing together experts on ligand (E Hope, M Wills) and catalyst (E Hope, D Cole-Hamilton) synthesis, catalyst testing, optimisation and mechanistic studies (D Cole-Hamilton), reactor design (G Manos) and multiphase flow (P Angeli) in order to develop the fluorous biphase concept so that it can become a serious candidate for commercialisation of these important reactions.EngProg\
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Organisation Website: http://www.st-and.ac.uk