| EPSRC Reference: |
GR/N03372/01 |
| Title: |
CONSTRAINING PEPTIDES WITH NORBORNENE UNITS |
| Principal Investigator: |
North, Professor M |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
Kings College London |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 1999 |
Ends: |
30 September 2002 |
Value (£): |
55,102
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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This project is concerned with the synthesis of peptide analogues constrained to adopt parallel or anti-parallel beta-sheets. The constraint will be enforced by a norbornene unit and the work builds upon preliminary results which have proven the concept. The project will first investigate whether the norbornene constraints can impose beta-sheet formation on peptide sequences even if they do not contain amino acids which are prone to beta-sheet formation, and then determine how far along a peptide chain a single norbornene unit can induce beta-sheet formation. The modification of the norbornene residue to produce water soluble beta-sheets will be investigated as will the synthesis of more complex beta-sheet architectures comprising three or more peptide strands.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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