| EPSRC Reference: |
GR/N02481/01 |
| Title: |
A NEW STEREOSELECTIVE APPROACH TO CYCLOBUTANOLS: FROM BUILDING BLOCKS TO BIOACTIVE MOLECULES |
| Principal Investigator: |
Procter, Professor DJ |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
School of Chemistry |
| Organisation: |
University of Glasgow |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 2000 |
Ends: |
30 September 2003 |
Value (£): |
53,067
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| EPSRC Research Topic Classifications: |
| Asymmetric Chemistry |
Biological & Medicinal Chem. |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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This proposal aims to develop a new and original approach to the preparation of cyclobutanols. The approach will be stereoselective thus allowing complex molecules to be assembled rapidly with complete control of the product molecule's shape. Cyclobutanols are important organic structures which are found in biologically active molecules and are often used as intermediates for the synthesis of more complex compounds. A solid phase/combinatorial approach will be employed to speed up the usually slow process of developing a new synthetic reaction. The first total synthesis of the Pestalotiopsin natural products will then be used to illustrate the use of the new chemistry, and will allow the biological properties and pharmaceutical potential of these newly isolated compounds to be fully assessed.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.gla.ac.uk |