Details of Grant 

EPSRC Reference:	GR/N00500/01
Title:	REGIOSELECTIVE INDOLOCARBAZOLE ALKALOID SYNTHESIS:ASY- MMETRIC REACTIONS OF BISINDOYLMALEIMIDE CYCLOPHANES
Principal Investigator:	Nelson, Professor AS
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department:	Sch of Chemistry
Organisation:	University of Leeds
Scheme:	Standard Research (Pre-FEC)
Starts:	01 October 2000	Ends:	30 September 2003	Value (£):	53,341
EPSRC Research Topic Classifications:	Chemical Synthetic Methodology
EPSRC Industrial Sector Classifications:	Chemicals Pharmaceuticals and Biotechnology No relevance to Underpinning Sectors
Related Grants:
Panel History:
Summary on Grant Application Form
The indolocarbazole alkaloids are a class of natural products with a remarkable range of biological activity but a general regioselective synthesis has not been developed. We will tackle the problem of passing information between the southern and northern districts of these molecules by studying bisindoylmaleimide cyclophanes; these cyclophanes are precursors of indolocarbazole alkaloids and the conformation of their macrocyclic ring will relay information between the remote districts. The synthesis, configurational stability and asymmetric reactions of bisindoylmaleimide cyclophanes will be studied and the methods developed will be applied to the synthesis of analogues and members of the indolocarbazole class of alkaloids.
Key Findings
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Potential use in non-academic contexts
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Impacts
Description This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk Summary Date Materialised
Sectors submitted by the Researcher
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Project URL:
Further Information:
Organisation Website:	http://www.leeds.ac.uk