| EPSRC Reference: |
GR/M98999/01 |
| Title: |
PALLADIUM CATALYSED MOLECULAR QUEUING PROCESSES AND RELAY SWITCHES |
| Principal Investigator: |
Grigg, Professor R |
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| Department: |
Sch of Chemistry |
| Organisation: |
University of Leeds |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 1999 |
Ends: |
31 March 2003 |
Value (£): |
228,091
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| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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The new Millennium is an excellent time to critically reassess traditional organic synthesis and to move from the ponderous, inefficient, multistep sequential methods to cascade reaction design and implementation. This project seeks to contribute to this by inventing catalytic polymolecular queuing processes in which disparate reactants are assembled in a predictable and well defined way using Pd catalysts. This will involve evaluating a range of mono- and bi- and ti-functional molecular building blocks to assess their relative rates of reaction at a Pd CENTRE. These can then be incorporated in polymolecular queuing processes to assemble complex carbo- and hetero-cycles chemo-, regio- and sterio-selectivity. The resulting minimum or zero waste methodology will produce startling increases in molecular complexity that far outstrip conventional methodology and which allows interfacing with core organic reactions such as [4+2]- and [3+2]-cycloaddition processes. Applications of the methodology to unusual steroids, cnorins and other natural and bioactive synthetic products (eg peptide mimetics) will then be pursued.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.leeds.ac.uk |