| EPSRC Reference: |
GR/M98968/01 |
| Title: |
ROMPGEL AND RELATED SUPPORTS IN COMBINATORIAL CHEMISTRY |
| Principal Investigator: |
Barrett, Professor T |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
Imperial College London |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 2000 |
Ends: |
30 September 2003 |
Value (£): |
189,491
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| EPSRC Research Topic Classifications: |
| Chemical Biology |
Combinatorial Chemistry |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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Both ROMPGELS and ROMPSPHERES will be applied in both parallel and combinatorial syntheses. ROMPGELS, which are insoluble polymers derived from the ring opening metathesis polymerisation of polyfunctional strained alkenes using the Grubbs catalyst C12 (Cy3P) 2Ru=CHPh, are useful for the rapid synthesis of target pharmaceuticals in the solution phase but with greatly simplified purification. These novel supported reagents will be adapted for acylation and Mitsunobu reactions, diverse carbon-carbon bond constructions and oxidation reactions. ROMPSPHERES are high loading, large resin bead block copolymers derived from the coating ring opening metathesis polymerisation of polyfunctional strained alkenes starting from polystyrene resin beads lightly functionalised with ArCH=RuC12 (Cy3P) 2 residues (100-200 mesh, 0.06 mequiv.g-1). ROMPSPHERES have the potential for use in diverse chemical transformations of solid supported substrates with high bead loading and with high-mass recovery per bead. This should greatly simplify single bead per well bioassays following cleavage from the support and where necessary full compound authentication without recourse to tagging or deconvolution by resynthesis. The products from both ROMPGELS and ROMPSPHERES syntheses will be used to produce diverse sub-libraries of compounds for bioassay.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.imperial.ac.uk |