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Details of Grant 

EPSRC Reference: GR/M94885/01
Title: SURFACES TO ENHANCE TISSUE CULTURE OF SKIN
Principal Investigator: Short, Professor R
Other Investigators:
MacNeil, Professor S Leggett, Professor G
Researcher Co-Investigators:
Project Partners:
GlaxoSmithKline plc (GSK)
Department: Materials Science and Engineering
Organisation: University of Sheffield
Scheme: Standard Research (Pre-FEC)
Starts: 04 October 1999 Ends: 03 July 2003 Value (£): 116,630
EPSRC Research Topic Classifications:
EPSRC Industrial Sector Classifications:
Healthcare
Related Grants:
Panel History:  
Summary on Grant Application Form
This proposal is concerned with defining the optimal surfaces for the tissue culture of keratinocytes (skin cells). Keratinocyte attachment, proliferation and differentiation will be examined upon molecularly engineered plasma co-polymer surfaces. We will explore the interplay between specific surface functional groups and cell behaviour. Self assembeled monolayers will be used to validate the _esults. This will lead to an understanding of the functionalities responsible for aspects of cellular behaviour and allow the optimum surfaces for cell culture to be produced. Such surfaces will be of importance in the tissue engineering of skin. For example surfaces which promote proliferation will assist in cell multiplication from a limited donor sources, while those which maintain phenotype will :e of use in controlled pharmacological testing.
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Further Information:  
Organisation Website: http://www.shef.ac.uk