| EPSRC Reference: |
GR/M93413/01 |
| Title: |
SOLID-SUPPORTED REAGENTS FOR THE ENHANCEMENT OF ENANTIOMERIC EXCESS |
| Principal Investigator: |
Clayden, Professor J |
| Other Investigators: |
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| Department: |
Chemistry |
| Organisation: |
Victoria University of Manchester, The |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 February 2000 |
Ends: |
28 February 2003 |
Value (£): |
173,149
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| EPSRC Research Topic Classifications: |
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| Chemicals |
Pharmaceuticals and Biotechnology |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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High enantiomeric excess is essential for the synthesis of chiral compounds for biological applications, and is particularly important for the synthesis of chiral drugs and drug candidates. Many methods of asymmetric synthesis deliver lower than acceptable levels of enantiomeric excess, and several methods are in common use for ee ehancement - recrystallisation, for example. Our research programme sets out to find a general way of improving the ee of a variety of mono- and bifunctional compounds, whether crystalline or not. We aim to develop a reagent capable of reacting selectively with racemic pairs of substrate molecules, removing them from solution and leaving behind a sample of enhanced ee. The molecular recognition necessary to achieve this aim will be by means of conformational control: reaction of the reagent's first functional group with one enantiomer of the substrate will influence the conformation of the bifunctional reagent in such a way that reaction at a second site shows a strong preference for the other enantiomer of substrate. By mounting the reagent onto solid support we hope to develop a versatile method for ee enhancement which will involve simply stirring the substrate with the supported reagent, which will be recoverable by an acid wash.
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Key Findings |
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Potential use in non-academic contexts |
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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