| EPSRC Reference: |
GR/M90313/01 |
| Title: |
TOTAL SYNTHESIS OF MANZAMINE A AND RELATED ALKALOID NATURAL PRODUCTS |
| Principal Investigator: |
Coldham, Professor I |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
University of Exeter |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 February 2000 |
Ends: |
30 April 2003 |
Value (£): |
117,356
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
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| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
No relevance to Underpinning Sectors |
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| Related Grants: |
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| Panel History: |
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Summary on Grant Application Form |
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This proposal aims to provide a unique, highly efficient and rapid synthesis of the manzamine alkaloids. The chemistry involves, as its key step, a powerful and stereocontrolled intramolecular azomethine ylide cycloaddition. This process sets up two new rings and three new chiral centres in a single step, to provide, starting from easily-prepared ring A and ring E substrates, the ABCE rings of the manzamines. Ring D will be constructed from this tetracylce and the total synthesis completed in the shortest and most efficient route to date. The manzamines are an important class of marine alkaloids with significant biological activity as antileukemic and antibacterial agents.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.ex.ac.uk |