| EPSRC Reference: |
GR/M88242/01 |
| Title: |
KINETIC STUDIES OF ENANTIOSELECTIVE HECK COUPLING REACTIONS |
| Principal Investigator: |
Blackmond, Professor DG |
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| Department: |
Chemistry |
| Organisation: |
University of Hull |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 July 1999 |
Ends: |
30 June 2000 |
Value (£): |
50,064
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| EPSRC Research Topic Classifications: |
| Catalysis & Applied Catalysis |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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Asymmetric catalysis is one of the fastest growing areas both in academic study and for commercial application in the pharmaceutical and fine chemicals industries. Most approaches to research in asymmetric catalysis have focussed on the three-dimensional steric aspects of chiral discrimination in these reactions; however, a number of examples have shown that product enantioselectivity may in many cases be dictated primarily by kinetic influences, the so-called fourth dimension of chiral catalysis. Therefore accurate kinetic measurements are becoming a key to obtaining a fundamental understanding of asymmetric catalytic reactions. This proposal aims to develop reaction microcalorimetry as a valuable kinetic tool for accurate in-situ measurements of reaction rate in asymmetric catalytic reactions. The kinetics and mechanisms of the enantioselective Heck coupling of aryl triflates with dihydrofuran will be studied as an example of a selective stereodivergent composite reaction process. Novel Pd complexes with ferrocenyl ligands have been shown to be significantly more active than previously studied systems. These systems inhibit intriguing reaction rate characteristics and a conversion-dependent enantioselectivity. Kinetic measurements combined with spectroscopic and analytical information will help to further our understanding of the complex reaction processes which characterise many asymmetric catalytic reaction networks.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.hull.ac.uk |