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EPSRC Reference: GR/M72371/01
Title: COMBINING OPTICAL AND ULTRASOUND IMAGING FOR SKIN LESION DIAGNOSIS FOR EVENTUAL USE AT PRIMARY CARE LEVEL
Principal Investigator: Bamber, Professor JC
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Cortex Technology APS Royal Marsden Hosp/NHS Trust
Department: Physics
Organisation: Institute of Cancer Research
Scheme: Standard Research (Pre-FEC)
Starts: 01 October 1999 Ends: 31 March 2003 Value (£): 243,467
EPSRC Research Topic Classifications:
Image & Vision Computing Instrumentation Eng. & Dev.
EPSRC Industrial Sector Classifications:
No relevance to Underpinning Sectors Healthcare
Related Grants:
Panel History:  
Summary on Grant Application Form
It is proposed to investigate a combination of high frequency ultrasound and optical imaging with a view to determining whether such a system could form the basis of a primary-care diagnostic aid. New kinds of microscopic ultrasonic images will be produced of surface reflection, attenuation and skin topography, which may be viewed and analysed in registration with the optical skin surface micrograph. Improved methods of hair-image and specular reflection artefact removal will be explored together with correction for non-uniform illumination and limited depth of focus in optical images. Optical image segmentation (boundary detection) based on edge-focusing will be compared with snakes and a new colour region-based agglomerative clustering (mRAC) method. Segmentation will be used to guide automatic feature extraction from both optical and ultrasound images. Skin pattern disruption (greater by malignant lesions) measured from the optical image and ultrasound profilometry will be quantified and compared. A set of lesion features (size, bulkiness, asymmetry, edge acutance, boundary fractal dimension, degree and area of inflammation and degree of skin pattern disruption, intensity, texture, lesion:background contrast) from the optical and ultrasound images will be used in a multivariate analysis to predict lesion type from a set of lesions of known histological type.
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