Details of Grant 

EPSRC Reference:	GR/M70247/01
Title:	INTEGRATING DETECTION AND PROCESSING INTO MINIATURISED CHROMATOGRAPHY SYSTEMS
Principal Investigator:	Goodall, Professor DM
Other Investigators:	Allinson, Professor NM
Researcher Co-Investigators:
Project Partners:	Centre DE Recherche Nestle GlaxoSmithKline plc (GSK) Pfizer Purdue University Syngenta
Department:	Chemistry
Organisation:	University of York
Scheme:	Standard Research (Pre-FEC)
Starts:	01 July 1999	Ends:	30 September 2001	Value (£):	107,519
EPSRC Research Topic Classifications:	Analytical Science
EPSRC Industrial Sector Classifications:	No relevance to Underpinning Sectors
Related Grants:
Panel History:
Summary on Grant Application Form
Though there is a high activity in microfabricated analytical systems, both in the UK and elsewhere, there is considerably less effort on the matching provision of effective illumination, detection and processing. This project aims to restore this imbalance. It exploits the existing synergy between experts in separation science, its instrumentation and advanced signal processing. Its broad objective is to integrate efficient micro-optical and detection systems, together with current digital signal processing techniques, with microfabricated wafer scale liquid chromatography and electrophoresis systems currently being developed by Professor Regnier (Purdue University, USA). In addition to providing direct visualisation of separations, our goal is to use the high linear dynamic range and spatial resolution of the detector to provide quantitative descriptions of all phases of separation and microanalytical processes. For example, using CCD imaging and feedback control of electrodrive voltage, reagent zones can be stopped precisely at the time of optimum overlap, then demixed at any time afterwards. The project tackles a number of the fundamental research themes identified in this EPSRC Programme - namely, enhanced information recovery and miniaturisation - yet remains tightly bound, through our industrial collaborators, with the needs of industry.
Key Findings
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Potential use in non-academic contexts
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Impacts
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Project URL:
Further Information:
Organisation Website:	http://www.york.ac.uk