| EPSRC Reference: |
GR/M68596/01 |
| Title: |
CHIRAL OXIME ETHERS IN ASYMMETRIC SYNTHESIS |
| Principal Investigator: |
Moody, Professor CJ |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
University of Exeter |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 1999 |
Ends: |
30 September 2002 |
Value (£): |
62,647
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| EPSRC Research Topic Classifications: |
| Asymmetric Chemistry |
Combinatorial Chemistry |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
| No relevance to Underpinning Sectors |
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| Panel History: |
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Summary on Grant Application Form |
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It is proposed to develop the chemistry of chiral oxime ethers derived from (R) - and (S0 -0- (1-phenylbutyl) hydroxylamine [ROPHy and SOPHy] in asymmetric synthesis. Thus it is proposed to develop an improved asymmetric synthesis of alpha-aminoacids, especially non-proteinogenic and alpha-alkylated aminoacids. We will also investigate the metallation chemistry of chiral oxime ethers, in particular alpha-lithiation and beta-palladation, as a method for the asymmetric alkylation of aldehydes and ketones and functionalisation of inert alkyl groups respectively. The use of ROPHy/SOPHy oximes in combination with the ring closing metathesis reaction (RCM) will be developed as a powerful route to chiral cyclic amines. Finally it is proposed to develop a solid phase variant of the reaction for use in combinatorial chemistry.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.ex.ac.uk |