EPSRC logo

Details of Grant 

EPSRC Reference: GR/M68596/01
Title: CHIRAL OXIME ETHERS IN ASYMMETRIC SYNTHESIS
Principal Investigator: Moody, Professor CJ
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department: Chemistry
Organisation: University of Exeter
Scheme: Standard Research (Pre-FEC)
Starts: 01 October 1999 Ends: 30 September 2002 Value (£): 62,647
EPSRC Research Topic Classifications:
Asymmetric Chemistry Combinatorial Chemistry
EPSRC Industrial Sector Classifications:
No relevance to Underpinning Sectors Chemicals
Pharmaceuticals and Biotechnology
Related Grants:
Panel History:  
Summary on Grant Application Form
It is proposed to develop the chemistry of chiral oxime ethers derived from (R) - and (S0 -0- (1-phenylbutyl) hydroxylamine [ROPHy and SOPHy] in asymmetric synthesis. Thus it is proposed to develop an improved asymmetric synthesis of alpha-aminoacids, especially non-proteinogenic and alpha-alkylated aminoacids. We will also investigate the metallation chemistry of chiral oxime ethers, in particular alpha-lithiation and beta-palladation, as a method for the asymmetric alkylation of aldehydes and ketones and functionalisation of inert alkyl groups respectively. The use of ROPHy/SOPHy oximes in combination with the ring closing metathesis reaction (RCM) will be developed as a powerful route to chiral cyclic amines. Finally it is proposed to develop a solid phase variant of the reaction for use in combinatorial chemistry.
Key Findings
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Potential use in non-academic contexts
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Impacts
Description This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Summary
Date Materialised
Sectors submitted by the Researcher
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Project URL:  
Further Information:  
Organisation Website: http://www.ex.ac.uk