| EPSRC Reference: |
GR/M68428/01 |
| Title: |
PHASE TRANSFER CATALYSTS WITH A CHIRAL ANION: ASYMMETRIC REACTIONS INVOLVING CATIONS |
| Principal Investigator: |
Nelson, Professor AS |
| Other Investigators: |
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| Department: |
Sch of Chemistry |
| Organisation: |
University of Leeds |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 1999 |
Ends: |
30 September 2002 |
Value (£): |
52,575
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| EPSRC Research Topic Classifications: |
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| Chemicals |
Pharmaceuticals and Biotechnology |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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The aim of the proposed research is to design and synthesise homochiral anions as chiral phase transfer catalysts for inducing asymmetry in reactions involving cationic intermediates. These reagents would have a very significant impact in many areas of asymmetric synthesis because their use would not be restricted to any particular reaction; for example, the Ritter reaction, the Mannich reaction and reductive amination are central to organic synthesis and do not have general catalytic asymmetric variants. The interactions between chiral anions and stable cations will be studied by X-ray crystallography. We shall study the configurational stability of anions with a chiral heteroatom by NMR or using chiral HPLC, allowing configurationally stable anions to be identified rapidly. An aspect of this work will involve anions with three elements of asymmetry; each of these axes of asymmetry is expected to act as a safety catch for the other two axes and these anions are expected to be more configurationally stable than simple anions. Homochiral anions will be synthesised either by resolution or by attaching homochiral ligands to a heteroatom; these anions will be used to induce asymmetry in reactions with cationic intermediates. Potential applications of this chemistry will be studied.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.leeds.ac.uk |