| EPSRC Reference: |
GR/M65045/01 |
| Title: |
HARDWARE AND SOFTWARE METHODS FOR POSITRON AUTORADIOGRAPHY |
| Principal Investigator: |
Wells, Dr K |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Sch of Electronics & Physical Sciences |
| Organisation: |
University of Surrey |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 1999 |
Ends: |
31 January 2003 |
Value (£): |
52,360
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| EPSRC Research Topic Classifications: |
| Instrumentation Eng. & Dev. |
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| EPSRC Industrial Sector Classifications: |
| Healthcare |
Pharmaceuticals and Biotechnology |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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This proposal is concerned with new methods in both hardware (instrumentation) and software (image/signal processing) for use in thin tissue autoradiography. The motivation for this proposal is driven by the need to overcome the limitations of poor sensitivity and quantification associated with using conventional film emulsion. The resulting hardware and software techniques will then be used to explore novel autoradiographic imaging methods currently precluded because of the limitations of the available technology.Although previous work in this area has resulted in greatly enhanced sensitivity, these systems have generally exhibited poor resolution compared to film. However, direct detection with a Charge Coupled Device (CCD) has shown promising results (~60% detection efficiency, ~30% resolution) using common beta emitters (S35, P33) encountered in autoradiography. This proposal builds on this work by extending operation to higher energies (up to 2 MeV) and higher temperatures (~300k). In order to achieve this aim, novel pixel thresholding and particle tracking algorithms will be developed. The results of this work will be used in the design and construction of a hybrid CCD autoradiography device. Preliminary investigations into novel autoradiographic imaging methods will then be undertaken using the new imaging system.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.surrey.ac.uk |