| EPSRC Reference: |
GR/M58009/01 |
| Title: |
UNSYMMETRIC COMPLLEXES AS MODELS FOR METALLOBIOSITES |
| Principal Investigator: |
Fenton, Professor D |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
University of Sheffield |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 1999 |
Ends: |
30 September 2002 |
Value (£): |
157,680
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
Co-ordination Chemistry |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
No relevance to Underpinning Sectors |
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| Related Grants: |
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| Panel History: |
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Summary on Grant Application Form |
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This project is designed to provide functional models for the asymmetric dimetallobiosites present in metalloenzymes such as urease (Ni,Ni); alkaline phosphatase [Zn,Zn]; purple acid phosphatase [Fe,Zn] and human protein phosphatase 1 [Mn,Fe]. It concerns the design and synthesis of a range of unsymmetrical ligands based on acyclic endogenous bridge Schiff bases; an investigation of the complexation properties of these ligands; the generation of homo- and hetero-dinuclear compounds; and studies of the reaction of the homo- and hetero-dinuclear compounds with urea and phosphate esters. It is anticipated that his latter aspect will shed light on the mechanisms available at dinuclear centres.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.shef.ac.uk |