| EPSRC Reference: |
GR/M46716/01 |
| Title: |
DEAROMATISING ANIONIC CYCLISATIONS OF ORGANOLITHIUMS |
| Principal Investigator: |
Clayden, Professor J |
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| Department: |
Chemistry |
| Organisation: |
Victoria University of Manchester, The |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 1999 |
Ends: |
30 September 2002 |
Value (£): |
48,097
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| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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New methods for the cheap and efficient synthesis of organic compounds, particularly those forming new C-C bonds, are vitally important for the pharmaceutical and fine chemicals industries. We aim to develop a new class of reactions based around the cyclisation of organolithiums onto aromatic rings. We will use cheap, simple aromatic starting materials to generate, in one simple but stereoselective cyclisation step, functionalised polycyclic products in which aromaticity has been destroyed. We shall exchange the reactivity of the organolithium and the customary unreactivity and stability of the aromatic ring for an array of synthetically versatile features. The majority of drugs are cyclic compounds, and we will go on to apply our new dearomatising cyclisation to the synthesis of some biologically active compounds from the kainoid (neuroexcitatory agents) and lignan (antitumour compounds) families.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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