| EPSRC Reference: |
GR/M37677/01 |
| Title: |
SYNTHESIS OF BRANCHED CARBOHYDRATES INCORPORATING BETA LINKED MANNOSE, MANNOSAMINE AND 2-DEOXYGLYCOSIDE UNIT |
| Principal Investigator: |
Osborn, Professor H |
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| Department: |
Chemistry |
| Organisation: |
University of Reading |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 August 1999 |
Ends: |
31 July 2002 |
Value (£): |
151,301
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| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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As a result of recent scientific advances which demonstrate the importance of carbohydrates within a whole array of different processes, there is a need for efficient syntheses of carbohydrates. This research proposal aims to develop new, efficient strategies for the synthesis of highly branched carbohydrates captaining beta-linked mannose, mannosamine and 2-deoxygloside units. Such linkages are often considered the most difficult to form efficiently by synthetic carbohydrate chemists. We wish to fully develop preliminary results obtained in our laboratory which have demonstrated that orthogonally protected C-2 oximes can favour beta-glycosidation if the conformation of the oxime is biased to favour that which causes steric hindrance of the bottom alpha-face. The syntheses of some orthogonally protected carbohydrates incorporating these beta-linked units will be performed to exemplify the power of our methodology. Indeed, the feasibility of linking the key oxime intermediate to a solid support to allow solid-phase synthesis of carbohydrates will also be investigated. If successful, this would greatly enhance our ability to rapidly synthesise biologically important carbohydrates. Both the syntheses of carbohydrates and the development of solid-phase chemistry have recently been identified as programme priorities by the EPSRC.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.rdg.ac.uk |