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Details of Grant 

EPSRC Reference: GR/M32603/02
Title: THE DEVELOPMENT OF MICRO-THERMAL ANALYSIS FOR THE CHARACTERISATION OF PHARMACEUTICAL MATERIALS
Principal Investigator: Craig, Professor D
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department: Sch of Pharmacy
Organisation: Queen's University of Belfast
Scheme: ROPA
Starts: 01 April 1999 Ends: 31 August 2000 Value (£): 49,979
EPSRC Research Topic Classifications:
Analytical Science
EPSRC Industrial Sector Classifications:
No relevance to Underpinning Sectors
Related Grants:
Panel History:  
Summary on Grant Application Form
This proposal describes the development of a novel thermoanalytical technique, micro-thermal analysis, for the characterisation of pharmaceutical materials. The technique combines the principles of atomic force microscopy with modulated differential scanning calorimetry, as the scanning tip of the former is fitted with a temperature probe which allows generation of a modulated heating signal to specific regions of the sample. Consequently, it is possible not only to identify different phases on a microscopic level via their thermal properties but also their individual melting, glass transitional and thermomechanical properties. We intend to develop the use of this exciting new approach within the pharmaceutical sciences, looking specifically at compressed tablets, powder mixes, partially amorphous materials and polymeric drug delivery system.
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Summary
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Organisation Website: http://www.qub.ac.uk