Details of Grant 

EPSRC Reference:	GR/M31958/01
Title:	JREI:A MASS SPECTROMETER FOR SYNTHETIC AND BIOLOGICAL CHEMISTRY
Principal Investigator:	Moody, Professor CJ
Other Investigators:	Bruce, Professor D Tucker, Professor JH Littlechild, Professor JA Coldham, Professor I Shipman, Professor M
Researcher Co-Investigators:
Project Partners:	Micromass UK Ltd (Waters Corporation)
Department:	Chemistry
Organisation:	University of Exeter
Scheme:	JREI
Starts:	09 March 1999	Ends:	08 March 2002	Value (£):	55,609
EPSRC Research Topic Classifications:	Biological & Medicinal Chem. Chemical Synthetic Methodology
EPSRC Industrial Sector Classifications:	Chemicals
Related Grants:
Panel History:
Summary on Grant Application Form
The proposed research covers a number of topics in biological and synthetic chemistry, most of which are concerned with the development of biologically active compounds. Thus the chemotherapy of cancer is being actively investigated with the development of new agents based on indolequinones, the azinomycins and manzamines; the key activation of indolequinones with reductases is also being studied. Diaziridine mimics of natural sugars will also be studied as will new routes to bioactive pyrrolidine alkaloids. A major study on thiopeptide antibiotics (synthesis and mechanism of action) will be initiated. Studies on the cloning, protein overexpression, biochemical characterisation and structural determination of a number of key enzymes involved in biotransformation reactions and of medical importance will continue within the protein structure group. In collaboration with this group it is proposed to investigate model complexes of the vanadium haloperoxidases, and supramolecular complexes of carboxylates, amino acides, and catecholamines. Novel liquid crystalline systems will also be investigated.
Key Findings
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Potential use in non-academic contexts
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Project URL:
Further Information:
Organisation Website:	http://www.ex.ac.uk