| EPSRC Reference: |
GR/M20891/01 |
| Title: |
A TRULY CONCISE SYNTHESIS OF FORSKOLIN: CHALLENGING CONTEMPORARY SYNTHETIC METHODOLOGY |
| Principal Investigator: |
Simpkins, Professor NS |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Department: |
Sch of Chemistry |
| Organisation: |
University of Nottingham |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
19 October 1998 |
Ends: |
18 May 2001 |
Value (£): |
97,267
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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The main aim of the proposed work is to explore a remarkably short synthetic entry to the natural product forskolin. During the course of these studies, we aim to address a number of substantial challenges, including the issue of reversibility in aldol reactions between hindered partners and the use of ring-opening-closing alkene metathesis reactions for the construction of polycyclic intermediates having the forskolin skeleton. The use of alkene metathesis in such situations will also be examined in a more general sense, and when combined with rapid synthesis of functionalised precursors using the chiral base approach, it may lead to a useful new synthetic strategy.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.nottingham.ac.uk |