EPSRC logo

Details of Grant 

EPSRC Reference: GR/M16962/01
Title: DISSECTING METAL ION CATALYSED PHOSPHATE HYDROLYSIS
Principal Investigator: Williams, Professor NH
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department: Chemistry
Organisation: University of Sheffield
Scheme: Standard Research (Pre-FEC)
Starts: 01 October 1999 Ends: 30 September 2002 Value (£): 48,874
EPSRC Research Topic Classifications:
Physical Organic Chemistry
EPSRC Industrial Sector Classifications:
Pharmaceuticals and Biotechnology Chemicals
No relevance to Underpinning Sectors
Related Grants:
Panel History:  
Summary on Grant Application Form
This proposal is for a detailed physical organic investigation into the role of metal ions in catalysing phosphate monoester and diester hydrolysis. Several lines of study are proposed, aimed at measuring quantitatively the effect of thio substitution at phosphorus in this context, the effect of combining further catalytic modes of action and in creating a link between mechanistically useful ions such as Co(III) and biologically interesting ions such as Zn(II). This will be achieved through kinetic analysis of defined complexes, where the contact between phosphates and metal ion are known, and where the mechanism of action can be shown. Based on the initial results, we will be able to construct more complexe models, making efficient use of any synthetic effect. The results will be applicable to understanding important biological catalysts which utilise metal ions for catalysis and to designing better artificial catalysts.
Key Findings
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Potential use in non-academic contexts
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Impacts
Description This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Summary
Date Materialised
Sectors submitted by the Researcher
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Project URL:  
Further Information:  
Organisation Website: http://www.shef.ac.uk