| EPSRC Reference: |
GR/M11042/01 |
| Title: |
CHIRAL AUXILIARIES WHICH ARE RACEMIC AND CATALYTIC |
| Principal Investigator: |
Williams, Professor JM |
| Other Investigators: |
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| Department: |
Chemistry |
| Organisation: |
University of Bath |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
28 September 1998 |
Ends: |
27 September 2001 |
Value (£): |
43,496
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| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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The proposed research will consider the possibility of using auxiliaries which are both rcemic and catalytic. The first aspect of the work will consider an enzyme-catalysed asymmetric acylation of a racemic auxiliary. Standard chiral auxiliaries will be used in their racemic forms, as well as other possibilities which could be looked at.In order for a catalytic reaction to be achieved, the substrate must react more quickly in the presence of the auxiliary. The electronic deactivation of enoic acids upon deprotonation is developed as a theme.These ideas are combined in efforts towards Diels Alder reactions, although other reactions are also outlined.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.bath.ac.uk |