| EPSRC Reference: |
GR/M04532/01 |
| Title: |
TAILORED GADOLINIUM COMPLEXES AND CONJUGATES |
| Principal Investigator: |
Parker, Professor D |
| Other Investigators: |
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| Department: |
Chemistry |
| Organisation: |
Durham, University of |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 September 1998 |
Ends: |
31 August 2001 |
Value (£): |
153,717
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| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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Paramagnetic contract agents for MRI will be prepared and characterised in collaboration with EU-COST-D8 partners. The factors determining pH-dependent relaxivity in the range 5.5 to 7.5 will be studied, examining a range of structurally related and kinetically robust 7 and 8-co-ordinate complexes. Both targeted Gd complexes (via folate conjugation) and motionally-coupled conjugates with relatively low MW but high intrinsic relaxivities, involving biocompatible gamma cyclodextrin or amino-dextrans will be prepared and studied in detail.
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Key Findings |
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Potential use in non-academic contexts |
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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