| EPSRC Reference: |
GR/L84995/01 |
| Title: |
JREI: A FIVE STATION KNEE JOINT SIMULATOR |
| Principal Investigator: |
Fisher, Professor J |
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| Department: |
Mechanical Engineering |
| Organisation: |
University of Leeds |
| Scheme: |
JREI |
| Starts: |
28 April 1998 |
Ends: |
27 April 2001 |
Value (£): |
62,000
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Summary on Grant Application Form |
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Wear debris induced osteolysis which causes long term loosening and failure of artificial joints is one of the major problems facing the orthopaedic community today. In the knee, ultra high molecular weight polyethylene (polyethylene) wear particles have been cited as a major cause of failure. ecent research has identified high contact stresses and oxidative degradation of polyethylene as accelerating factors. The industry is now looking towards low contact stress designs, and alternative methods of processing and sterilizing polyethylene to reduce wear and osteolysis. Assessment of the osteolytic potential involved measurement of wear volumes, analysis of the number and morphology of the wear particles generate and determination of the specific biological activity through in vitro cell culture models. The full portfolio of these research tools only reside in a few research groups in the world. Leeds University os one such centre.A five station knee joint simulator will be purchased to investigate wear debris induced osteolysis in artifical knee joints. In particular the machine will be used to investigate the three following key areas.The osteolytic potential of non crosslinked and crosslinked polyethylene in artificial knee joints.The osteolytic potential of low contact stress meniscal knee designs and higher contact stress fixed bearing designs.The application of surface coatings and modification to the femoral and tibial surfaces to reduse wear.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.leeds.ac.uk |