| EPSRC Reference: |
GR/L83134/01 |
| Title: |
MEDIATION OF CARBOHYDRATE REACTIVITY BY METAL CHELATE FORMATION |
| Principal Investigator: |
Osborn, Professor H |
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| Department: |
Chemistry |
| Organisation: |
University of Reading |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 1998 |
Ends: |
30 September 2001 |
Value (£): |
50,335
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| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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As a result of recent scientific advances which demonstrate the importance of carbohydrates within a whole array of different processes, there is a need for efficient syntheses of carbohydrates. The structures of carbohydrates are always complicated and these compounds are therefore notoriously difficult to prepare in a concise manner by traditional synthetic methods. Our work will address this problem by developing methods to activate a specific hydroxyl group decorating the carbohydrate ring. This will then permit subsequent regioselective reactions to be performed, without extensive requirement for protecting group strategies. We aim to achieve this selective activation by formation of copper chelates of the carbohydrate polyols. Although highly effective, the use of copper chelates to activate specific hydroxyl groups has so far been illustrated in only a limited number of cases. We now wish to extend this reaction to allow synthesis of monosaccharide and disaccharide building blocks, which are useful for on-pot oligosaccharide assembly strategies. The ability of the activated hydroxyl group to form glycosidic bonds with carbohydrate donors will also be investigated to allow direct assembly of oligosaccharide without the need for extensive protecting group strategies.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.rdg.ac.uk |