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Details of Grant 

EPSRC Reference: GR/L74835/01
Title: COMPUTER MODELLING OF THE HUMAN RESPIRATORY SYSTEM IN ADULT INTENSIVE CARE
Principal Investigator: Tilley, Dr DG
Other Investigators:
Miles, Professor AW
Researcher Co-Investigators:
Project Partners:
Department: Mechanical Engineering
Organisation: University of Bath
Scheme: Standard Research (Pre-FEC)
Starts: 01 April 1998 Ends: 31 December 2000 Value (£): 87,133
EPSRC Research Topic Classifications:
Intelligent & Expert Systems
EPSRC Industrial Sector Classifications:
No relevance to Underpinning Sectors
Related Grants:
Panel History:  
Summary on Grant Application Form
Using a previously developed mathematical model of the human respiratory system as a starting point, we propose to develop a mathematical model of the respiratory system of artificially ventilated patients on the adult general ICU. Physiological data from 50 patients who are invasively monitored as part of their routine care will be used to review the models of the respiratory system and determine the parameters within the model which require quantification but cannot be measured directly. A further 50 patients studies will be partitioned on demographic and severity of illness and differences between the model predictions and the measured values will not only be assessed quantitatively but they will also be assessed qualitatively in terms of their clinical significance. The long term aim of the research, if the development of the respiratory models is successful, so to develop a bedside decision support system which will support both prescribing an artificial ventilation regime and proactive monitoring of its efficacy.
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Organisation Website: http://www.bath.ac.uk