Details of Grant 

EPSRC Reference:	GR/L69244/01
Title:	POLY-CATENANE SYNETHESIS UNDER THERMODYNAMIC CONTROL
Principal Investigator:	Sanders, Professor J
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department:	Chemistry
Organisation:	University of Cambridge
Scheme:	Standard Research (Pre-FEC)
Starts:	01 September 1997	Ends:	31 October 2000	Value (£):	153,704
EPSRC Research Topic Classifications:	Chemical Synthetic Methodology
EPSRC Industrial Sector Classifications:	No relevance to Underpinning Sectors
Related Grants:
Panel History:
Summary on Grant Application Form
We propose to combine donor-acceptor templating (using neutral robust building blocks) with thermodynamically controlled ring synthesis to give chemically versatile poly-catenanes. Use of removable blocking groups and a ring fixing reaction will give access to well defined poly-catenanes with new architectures. More importantly, this specific catenane proposal is a vehicle for exploring a general strategy for covalent synthesis of nanoscale objects. We propose to exploit a hierarchy of three types of covalent bond formation for the programmed generation of large rings: kinetically controlled, irreversible reactions; Thermodynamically-controlled, reversible reactions (transesterification and imine-formation); and ring fixing reactions (imine reduction).
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Organisation Website:	http://www.cam.ac.uk