| EPSRC Reference: |
GR/L60951/01 |
| Title: |
CASCADE RADICAL PROCESSES: RAPID POLYCYCLE CONSTRUCTIONS AND TARGET SYNTHESIS |
| Principal Investigator: |
Pattenden, Professor G |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Sch of Chemistry |
| Organisation: |
University of Nottingham |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 January 1998 |
Ends: |
30 June 2001 |
Value (£): |
146,124
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| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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Illustrations of the scope for a wide range of radical-mediated cascade ring-forming reactions are rife in the contemporary literature. Our own research group has contributed in a significant way to these developments, and new and novel strategies to a range of biologically important polycyclic constructs have been forthcoming. The project plans to develop this general area by : a) introducing and developing new electrophores e.g. cyclopropane and letene; b) incorporating design, i.e. pre-organised acyclic chains and tethers; c) exploring radical-accelerated Diels-Alder, electrocyclic and Paulson-Khand processes, in concert with radical cyclisation; d) expanding our recently discovered method for steroid-ring constructions from polyene acyl radicals, via sequential 6-endo-trig cyclisations, to bio-active steroids and their analogues; e) applying the principles of cascade radical processes in the synthesis of meaningful synthetic targets of biological importance , e.g. taxol, steroids, poly-quinanes.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.nottingham.ac.uk |