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Details of Grant 

EPSRC Reference: GR/L58583/01
Title: DESIGN OF SUBSTRATE MATERIALS FOR CONTROL OF CELL GROWTH
Principal Investigator: Liggat, Professor J
Other Investigators:
Pethrick, Professor RA Curtis, Professor ASG Wilkinson, Professor C
Researcher Co-Investigators:
Project Partners:
Pre Nexus Migration
Department: Pure and Applied Chemistry
Organisation: University of Strathclyde
Scheme: Standard Research (Pre-FEC)
Starts: 01 October 1997 Ends: 30 September 2000 Value (£): 200,032
EPSRC Research Topic Classifications:
EPSRC Industrial Sector Classifications:
No relevance to Underpinning Sectors
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Panel History:  
Summary on Grant Application Form
This proposal outlines a unique multi-disciplinary collaboration bringing together the skills and resource base of polymer chemists, cell biologists and microfabrication experts at the Universities of Strathclyde and Glasgow with the objective of designing and constructing biomedical implants for enhancing tissue regeneration. An already extensive knowledge of cell adhesion and the response of cells to micro and nano structures will be translated into practical devices.Specifically the proposed research seeks to optimise the production of biodegradable and biocompatible embossed films on structured fibre devices based predominantly on polyhydroxybutyrate and other aliphatic polyesters. Factors such as the infulence of plasticisers, fillers and conditions such as temperature on processing will be determined. Devices will be characterised chemically, physcially and biologically to ensure the optimisation of mechanical properties, lifetime upon implantation and cell response. Subject to sucessful trial in vitro, devices will be offered to partners in other programmes for trials in vivo.
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Organisation Website: http://www.strath.ac.uk