| EPSRC Reference: |
GR/L58064/01 |
| Title: |
CONVERTING THE STOICHIOMETRIC SULFUR YLIDE REACTION INTO A CATALYTIC PROCESS |
| Principal Investigator: |
Aggarwal, Professor VK |
| Other Investigators: |
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| Department: |
Chemistry |
| Organisation: |
University of Sheffield |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 November 1997 |
Ends: |
28 February 2001 |
Value (£): |
141,735
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| EPSRC Research Topic Classifications: |
| Catalysis & Applied Catalysis |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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Epoxides can be prepared from carbonyl compounds using sulfur ylides but the process suffers in requiring stoichiometric amounts of sulfides. We are proposing to convert this reaction into a catalytic process and in particular to develop a process for the preparation of terminal epoxides. Towards this endeavour we have recently discovered a novel catalytic cycle for epoxidation of carbonyl compounds using a sulfide and a combination of Et2Zn/CH2ICl (Simmons Smith). To make the process catalytic in sulfide we have found that use of chelating ligands for zinc allows sub-stoichiometric amounts of sulfides to be used. Furthermore, we have found that such ligands also result in rate acceleration. We will test a range of achiral and chiral ligands to improve the turnover of the sulfide. We will then prepare chiral sulfides and develop a method for catalytic asymmetric epoxidation. Finally. we intend to use the concept of molecular robots for asymmetric epoxidation. In this process, both the ylide and the carbonyl compound are activated towards reaction on a metal template. This should result in higher reactivity, improved rates and selectivity.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.shef.ac.uk |