| EPSRC Reference: |
GR/L57319/01 |
| Title: |
NON-AQUEOUS CONDITIONS FOR POLYAMINO ACID-CATALYSED ASYMMETRIC OXIDATIONS |
| Principal Investigator: |
Roberts, Professor S |
| Other Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
University of Liverpool |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
20 October 1997 |
Ends: |
19 October 1998 |
Value (£): |
49,391
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| EPSRC Research Topic Classifications: |
| Catalysis & Applied Catalysis |
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| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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New non-aqueous reaction conditions has been shown to be highly advantageous for the polyleucine-catalysed asymmetric epoxidation of some simple a, b -unsaturated ketones. This proposal aims to capitalise on this discovery so as to ascertain the full range of substrates that will undergo asymmetric oxidation. Other enones (e.g. cyclic systems) and unsaturated keto esters will be used as substrates. Unsaturated esters, nitroalkenes, vinylcyanides and vinylsulfones will also be investigated. The oxidation will be extended to ketones (baeyer-Villiger oxidations) and a sulfide. Purchase of oligomers of polyeucine will allow the optimum chain-length of the catalyst to be ascertained and will prompt initial studies into the mechanism of this intriguing oxidation reaction.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.liv.ac.uk |