Details of Grant 

EPSRC Reference:	GR/L41967/02
Title:	MOVING BOUNDARIES AND NONLINEAR WAVES MODELLING THE ROLE OF P53 IN TUMOUR GROWTH
Principal Investigator:	Lewis, Professor C
Other Investigators:	Sherratt, Professor JA Byrne, Professor H Royds, Dr J
Researcher Co-Investigators:
Project Partners:
Department:	Sch of Mathematical Sciences
Organisation:	University of Nottingham
Scheme:	Standard Research (Pre-FEC)
Starts:	01 October 1998	Ends:	31 August 2000	Value (£):	45,705
EPSRC Research Topic Classifications:	Theoretical biology
EPSRC Industrial Sector Classifications:	No relevance to Underpinning Sectors
Related Grants:
Panel History:
Summary on Grant Application Form
Recant advances in the cellular mechanisms underpinning tumour growth have outstripped the power of existing mathematical frameworks. the recent Applied Nonlinear Mathematics Workshop held in Warwick in September 1996 highlighted this discrepancy and acted as a catalyst for this project. To redress the current imbalance between mathematics and experimental biology we propose the development and analysis of a new generation of models, based on existing biological data. Their study will require mathematical approaches, including problems with multiple moving boundaries and nonlinear wave equations. These mathematical challenges are the essential novelty in this project. The models will be studied analytically and numerically to show how the resulting behaviour depends on key biological parameters. The detailed modelling will focus on the influence that changes in the cell environment and mutations in the tumour suppressor gene p53 exert on the growth of vascular and early vascular tumours. We will focus on p53 since mutation of this gene is a key event in tumour progression. Further, since human tumours processes higher levels of p53 than normal tissue, it is hoped that the design of drugs which bind preferentially to, of block the actions of, mutant p53 will improve the management of cancer. this the mathematical conclusions will generate both novel mathematics and practical approaches for tackling tumour growth, and breast cancer in particular.
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Organisation Website:	http://www.nottingham.ac.uk