| EPSRC Reference: |
GR/L37120/01 |
| Title: |
DYNAMIC KINETIC RESOLUTION REACTIONS WITH ENZYMES AND TRANSITION METALS |
| Principal Investigator: |
Williams, Professor JM |
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| Department: |
Chemistry |
| Organisation: |
University of Bath |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 1997 |
Ends: |
30 September 2000 |
Value (£): |
45,739
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| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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The proposed work will examine the use of transition reactions. In particular, the racemisation of simple alcohols, aldol substrates and amines will be examined using hydrogen transfer catalysts. Lipases and esterases will be examined for their ability to perform dynamic resolution reactions on these substrates in the presence of the hydrogen transfer catalysts. The racemisation of appropriate aldol substrates will also lead to epimerisation between syn and anti aldol systems. Enzymes which identify one of four isomers will need to be identified.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.bath.ac.uk |