| EPSRC Reference: |
GR/L30770/01 |
| Title: |
ANIONIC CYCLIZATIONS-FUNDAMENTAL METHODOLOGY FOR STEREOCONTROLLED NITROGEN HETEROCYCLE SYNTHESIS |
| Principal Investigator: |
Coldham, Professor I |
| Other Investigators: |
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| Department: |
Chemistry |
| Organisation: |
University of Exeter |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 1997 |
Ends: |
30 September 2000 |
Value (£): |
50,308
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Summary on Grant Application Form |
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This proposal aims to illustrate the importance of two-electron (anionic) cyclisations as a fundamental method for the synthesis of cyclic amines. Organolithiums alpha to nitrogen will be generated by tin-lithiums alpha to nitrogen will be generated by tin-lithium exchange. The cyclization (onto an alkene, alkyne or carbonyl group) is expected to be stereocontrolled at the carbanion centre and the new chiral centre(s). This will allow the stereo- and enantio-selective synthesis of monocyclic amines, such as kainic acid and analogues, bycyclic amines, such as indolizidine 209B and slaframine, and bridged bicyclic amines, such as tropanes and epibatidine analogues.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.ex.ac.uk |