| EPSRC Reference: |
GR/L24939/01 |
| Title: |
TOWARDS THE PSEUDOPTEROSINS:AN EXERCISE IN THE CONTROL OF ABSOLUTE STEREOCHEMISTRY AT BENZYLIC CENTRES. |
| Principal Investigator: |
Harrowven, Professor DC |
| Other Investigators: |
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| Project Partners: |
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| Department: |
Sch of Chemistry |
| Organisation: |
University of Southampton |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 1997 |
Ends: |
30 September 2000 |
Value (£): |
50,308
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| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
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Summary on Grant Application Form |
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A rapid entry towards the pseudopterosins, a family of marine natural products with therapeutically significant anti inflammatory and analgesic activity, has been developed. Our present synthesis is inefficient and racemic. The proposal outlines a short and enantiospecific route to the pseudopterosins. Key features are 1) a nickel catalysed asymmetric coupling reaction; 2) an enantiospecific union of an organozinc and an aldehyde and 3) a Lewis acid mediated sequential cyclisation.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.soton.ac.uk |