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Details of Grant 

EPSRC Reference: GR/L09943/01
Title: ORGANOMETALLIC APPROACHES TO THE COLABOMYCIN/MANUMCIN ANTIBIOTICS
Principal Investigator: Taylor, Professor R
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department: Chemistry
Organisation: University of York
Scheme: Standard Research (Pre-FEC)
Starts: 01 October 1996 Ends: 30 September 1999 Value (£): 144,669
EPSRC Research Topic Classifications:
Chemical Synthetic Methodology
EPSRC Industrial Sector Classifications:
Related Grants:
Panel History:  
Summary on Grant Application Form
The colabomycin/manumycin family of 2-aminoepoxycyclohexenone antibiotic have generated a great deal of interest in view of their biological properties. In addition to antibacterial activity they are also anti-fungal, insecticidal and they inhibit polymorphonuclear elastase. Most exciting, however, is their potent and selective ability to inhibit ras-farnesyltransferase demonstrating great potential for cancer chemotherapy. To date, there are no syntheses of these natural products or their analogues in the literature although we and others have recently prepared related compounds. We have prepared the epoxycyclohexanone antibiotic (-)-aranorosin and the 2-bromoepoxycyclohexenone anti-tumour agents bromoxone. We now want to utilise this methodology to underpin a synthetic assault on the colabomycin/manumycin family of antibiotics. These studies will require the development of stereoselective and anantioselective routes to novel cyclohexanes and the development of stereoselective procedures for polyene synthesis and coupling and will thus be of general interest from the methodological view point. The synthetic route will also be employed to prepare novel, simplified colabomycin/manumycin analogues which will be screened for biological activity by pharmaceutical companies.
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Organisation Website: http://www.york.ac.uk