EPSRC Reference: |
GR/L09943/01 |
Title: |
ORGANOMETALLIC APPROACHES TO THE COLABOMYCIN/MANUMCIN ANTIBIOTICS |
Principal Investigator: |
Taylor, Professor R |
Other Investigators: |
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Researcher Co-Investigators: |
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Project Partners: |
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Department: |
Chemistry |
Organisation: |
University of York |
Scheme: |
Standard Research (Pre-FEC) |
Starts: |
01 October 1996 |
Ends: |
30 September 1999 |
Value (£): |
144,669
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EPSRC Research Topic Classifications: |
Chemical Synthetic Methodology |
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EPSRC Industrial Sector Classifications: |
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Related Grants: |
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Panel History: |
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Summary on Grant Application Form |
The colabomycin/manumycin family of 2-aminoepoxycyclohexenone antibiotic have generated a great deal of interest in view of their biological properties. In addition to antibacterial activity they are also anti-fungal, insecticidal and they inhibit polymorphonuclear elastase. Most exciting, however, is their potent and selective ability to inhibit ras-farnesyltransferase demonstrating great potential for cancer chemotherapy. To date, there are no syntheses of these natural products or their analogues in the literature although we and others have recently prepared related compounds. We have prepared the epoxycyclohexanone antibiotic (-)-aranorosin and the 2-bromoepoxycyclohexenone anti-tumour agents bromoxone. We now want to utilise this methodology to underpin a synthetic assault on the colabomycin/manumycin family of antibiotics. These studies will require the development of stereoselective and anantioselective routes to novel cyclohexanes and the development of stereoselective procedures for polyene synthesis and coupling and will thus be of general interest from the methodological view point. The synthetic route will also be employed to prepare novel, simplified colabomycin/manumycin analogues which will be screened for biological activity by pharmaceutical companies.
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Key Findings |
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Potential use in non-academic contexts |
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Impacts |
Description |
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Summary |
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Date Materialised |
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Sectors submitted by the Researcher |
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Project URL: |
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Further Information: |
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Organisation Website: |
http://www.york.ac.uk |