EPSRC logo

Details of Grant 

EPSRC Reference: GR/L08441/01
Title: IN VIVO FLUORESCENCE LIFETIME SENSING IN CLINICAL MEDICINE: RESEARCH INTO GLUCOSE MONITORING
Principal Investigator: Pickup, Professor J
Other Investigators:
Birch, Professor D
Researcher Co-Investigators:
Project Partners:
IBH Ltd (Glasgow)
Department: Chemical Pathology
Organisation: United Medical & Dental Schools
Scheme: Standard Research (Pre-FEC)
Starts: 17 February 1997 Ends: 16 February 2000 Value (£): 149,396
EPSRC Research Topic Classifications:
Lasers & Optics
EPSRC Industrial Sector Classifications:
Healthcare
Related Grants:
Panel History:  
Summary on Grant Application Form
The development of new technology for monitoring glucose concentrations in vivo in patients with diabetes mellitus is a worldwide health care priority. Measurement of glucose-induced changes in fluorescent lifetimes (rather than intensity) has several potential advantages over existing methods of glucose sensing and may produce a new generation of stable, accurate and predictable monitors of tissue biochemistry for use in clinical medicine. We intend to prepare fluorophore-labelled glucose-binding proteins, including concanavalin A and glucose oxidase, and test the hypothesis that glucose concentration-dependent changes in near-infrared fluorescent lifetimes of these probes occur which can form the basis of a specific, accurate and precise in vivo glucose assay. Instrumentation will be developed for cuvette and remote, fibre optic-based sensing of time-domain fluorescence using time-correlated single photon counting; the potential interference of light scattering in tissues will be investigated by fluorescence studies in tissue phantoms.
Key Findings
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Potential use in non-academic contexts
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Impacts
Description This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Summary
Date Materialised
Sectors submitted by the Researcher
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Project URL:  
Further Information:  
Organisation Website: