| EPSRC Reference: |
GR/L08441/01 |
| Title: |
IN VIVO FLUORESCENCE LIFETIME SENSING IN CLINICAL MEDICINE: RESEARCH INTO GLUCOSE MONITORING |
| Principal Investigator: |
Pickup, Professor J |
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| Department: |
Chemical Pathology |
| Organisation: |
United Medical & Dental Schools |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
17 February 1997 |
Ends: |
16 February 2000 |
Value (£): |
149,396
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Summary on Grant Application Form |
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The development of new technology for monitoring glucose concentrations in vivo in patients with diabetes mellitus is a worldwide health care priority. Measurement of glucose-induced changes in fluorescent lifetimes (rather than intensity) has several potential advantages over existing methods of glucose sensing and may produce a new generation of stable, accurate and predictable monitors of tissue biochemistry for use in clinical medicine. We intend to prepare fluorophore-labelled glucose-binding proteins, including concanavalin A and glucose oxidase, and test the hypothesis that glucose concentration-dependent changes in near-infrared fluorescent lifetimes of these probes occur which can form the basis of a specific, accurate and precise in vivo glucose assay. Instrumentation will be developed for cuvette and remote, fibre optic-based sensing of time-domain fluorescence using time-correlated single photon counting; the potential interference of light scattering in tissues will be investigated by fluorescence studies in tissue phantoms.
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Key Findings |
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Potential use in non-academic contexts |
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Impacts |
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| Description |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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